When a father-to-be is Rh negative and the mother-to-be
is Rh positive their baby could have Rh positive or
negative antibody and no risk is involved. Now reverse this scenario. The
mother-to-be is Rh negative, meaning she has no antibody
on her red blood cells, but her baby is Rh positive (the
baby inherited the characteristic from an Rh positive
father). The baby's blood can leak into the maternal blood
circulation system and react to the Rh component on the
surface of these blood cells as if it were a foreign
invader. The mother will automatically produce antibodies
to attach and fight against baby's Rh positive red blood
cell. For the baby this may cause the red cells to break
down, producing anemia in the fetus
Rhogam, a gamma globulin containing antibodies against
the Rh positive factor. By destroying any of the Rh
positive red cells that have migrated into the mother's
circulation from the fetus. Future Rh positive babies will
not be exposed to the Rh positive antibody.
Using Rhogam during and after pregnancy has largely
eliminated Rh disease.
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